Asymmetric distribution in twin screw granulation
نویسندگان
چکیده
منابع مشابه
Twin Screw Granulation – A Literature Review
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متن کاملDistribution of binder in granules produced by means of twin screw granulation.
According to the quality by design principle processes may not remain black-boxes and full process understanding is required. The granule size distribution of granules produced via twin screw granulation is often found to be bimodal. The aim of this study was to gain a better understanding of binder distribution within granules produced via twin screw granulation in order to investigate if an i...
متن کاملWet granulation in a twin-screw extruder: implications of screw design.
Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study endeavored to systematically examine t...
متن کاملSequential calculation of torque in procedure of twin screw extrusion
The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2016
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2016.01.013